Anatolius was at first a presbyter in the Church at Alexandria, but following the death of Patriarch Flavian, he was elevated to the patriarchal throne of Constantinople, in the year 449 A.D. During his time, the throne of Constantinople was recognized as equal to the throne of Rome, by the Ecumenical Council held in Chalcedon in 451 A.D. He struggled greatly for the purity of the Orthodox Faith and suffered much at the hands of the heretics, until he was slain by them in the year 458 A.D., during the reign of Pope Leo the Great. Anatolius governed the Church for nearly nine years, and took up his heavenly habitation among the holy hierarchs in the Kingdom of God.